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CBD Studies Database - Bioavailability

Did you know that the amount of CBD that is entering your system is dependent on a multitude of factors aside from what is written on the container? If you take it orally, topically, sublingually, or with food, the amount of CBD you are receiving may vary greatly. This is known as bioavailability, a subcategory of absorption that researchers are analyzing to better understand the variables that impact the absorption of CBD.

 

A phase I study to assess the effect of food on the single dose bioavailability of the THC/CBD oromucosal spray
This study’s purpose was to assess the effect of food on the single-dose bioavailability of delta-9-tetrahydrocannabinol (THC)/cannabidiol (CBD) spray, an endocannabinoid system modulator, when administered to healthy male subjects.
Read the full study here
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Model-Based Analysis of Cannabidiol Dose-Exposure Relationship and Bioavailability
This study aims to establish the CBD dose-exposure relationship and to evaluate the effects of dosage forms, food, and doses on CBD absorption.
Read the full study here. 
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Cannabidiol bioavailability after nasal and transdermal application: effect of permeation enhancers
Summary: This study has evaluated the intranasal and transdermal delivery of CBD with and without permeation enhancers.
Read the full study here.
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Critical Aspects Affecting Cannabidiol Oral Bioavailability and Metabolic Elimination, and Related Clinical Implications
Summary: This article provides a critical appraisal of the available evidence concerning clinical exposure to orally administered cannabidiol (CBD), with special reference to factors affecting gastrointestinal absorption, presystemic elimination, and susceptibility to metabolic drug interactions. 
Read the full study here.
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Towards Better Delivery of Cannabidiol (CBD)
Summary: This review identifies issues compromising current delivery of solid-state CBD, and how advanced pharmaceutical development strategies can enable CBD to realize the full potential as a successful therapeutic agent. 
Read the full study here.
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The effect of Pro NanoLipospheres (PNL) formulation containing natural absorption enhancers on the oral bioavailability of delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) in a rat model
Summary: This study explored the utility of an advanced lipid based Self-Emulsifying Drug Delivery System termed Advanced Pro-NanoLiposphere (PNL) pre-concentrate on CBD and THC oral bioavailability. 
Read the full study here.
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Development of a Novel Nano­emulsion Formulation to Improve Intestinal Absorption of Cannabidiol
Summary: This study developed a novel nanoemulsion preparation of CBD (CBD-NE) to improve the poor solubility and absorption of CBD. 
Read the full study here.
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PTL401, a New Formulation Based on Pro-Nano Dispersion Technology, Improves Oral Cannabinoids Bioavailability in Healthy Volunteers
Summary: This study compares the bioavailability of THC and CBD from the PTL401 capsule with similar doses from a marketed reference oromucosal spray (Sativex®). 
Read the full study here
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Natural sesame oil is superior to pre-digested lipid formulations and purified triglycerides in promoting the intestinal lymphatic transport and systemic bioavailability of cannabidiol
Summary: This study’s aim was to test the hypothesis that pre-digested lipid formulations (oleic acid, linoleic acid, oleic acid with 2-oleoylglycerol, oleic acid with 2-oleoylglycerol and oleic acid with glycerol) could reduce variability and increase the extent of the intestinal lymphatic transport and oral bioavailability of CBD. 
Read the full study here.

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